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Covid, immunity could last for years

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Coronavirus immunity lasts at least a year, but it could even remain for life. The news comes from two studies that analyzed people exposed to Coronavirus a year earlier and allays fears of having to resort to continuous vaccine boosters to maintain an efficient immune response. According to studies, the majority of those who have been hospitalized for Covid and have then been vaccinated do not need further boosters. Vaccinates who have never been infected with Sars-Cov-2 will likely need the injection, as will the minority of those infected who have not developed a robust immune response.

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According to the study just published in Nature – which was based on the analysis of sick patients the previous year – the cells that preserve the memory of the virus persist in the bone marrow and can produce antibodies whenever they are needed.

The other study – posted online at BioRxiv, a biological research site, found that so-called memory B cells continue to mature and strengthen for at least 12 months after the first vaccine injection.

“The studies are consistent with the ongoing scientific literature according to which the immunity resulting from the infection and vaccination for Sars-Cov-2 seems to last a long time”, he specified Scott Hensley, an immunologist at the University of Pennsylvania not involved in the research.

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In the case of coronaviruses that cause colds, immunity is short-lived. But these viruses have changed a lot over the years. “The reason we continually get infected with common coronaviruses over the course of our lifetimes may have a lot more to do with the fact that these viruses change all the time, rather than immunity,” Hensley said.

Memory B cells produced in response to Sars-Cov-2 infection and enhanced by vaccination are so powerful that they escape every variant of the virus, making a booster unnecessary, he explains. Michel Nussenzweig, an immunologist at Rockefeller University in New York, who conducted the study on the development of B callula memory.

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“People who have been infected and then vaccinated have a crazy response, a huge amount of antibodies because their antibodies continue to proliferate – Nussenzweig specified – and I expect this proliferation to last a very long time”.

However, this result may not be easily replicable in subjects who have only received the vaccine but have not been infected with the virus because the immune memory resulting from immunization is different from that caused by natural infection.

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