In the United States, a third dose of Moderna vaccine will be given to all frail individuals. The Advisory Committee of the FDA, Food and Drug Administration, unanimously voted for the emergency use of an additional dose of Covid vaccine for those over 65 and for all adults at risk of serious illness, at least six months from the completion of the first cycle.
An announcement that paves the way for a drastic expansion in the number of people eligible for further vaccination in the United States: a third dose of Modena had already been approved in August for those who are immunosuppressed or have undergone an organ transplant while a month ago is the FDA’s approval of a third Pfizer dose for people aged 65 and over. Seven million Americans have therefore already received a Pfizer booster dose, as well as more than a million patients with immune deficiencies have received the third dose of Moderna. Now the decision taken will greatly expand these numbers, opening up to all those who have previous pathologies or comorbidities that put them at risk of developing a severe form of Covid. This has already led the US pharmaceutical company to estimate a demand for one billion new doses by 2022.
Covid, Fauci: “Concerned by skeptics and No Vax, the third dose is a good idea”
by Gabriele Beccaria
A complete course of Moderna vaccine uses triple the amount of RNA-based active ingredient than Pfizer (100 micrograms instead of 30) and the decline in antibodies over time had appeared more modest in some studies. Now, according to the data provided by Moderna to the US authorities, an additional 50 microgram dose “shows strong immune responses against the original virus, but also against the Delta variant,” he said. Stephane Bancel, Chief Executive Officer of Moderna. “This recommendation is supported by our clinical data on the third dose.” virus and we look forward to making the new dose available to American citizens to help them protect themselves from the current health emergency. “
The Food and Drug Administration’s advisory board, made up of independent physicians, had the opportunity to review the scientific evidence provided by Moderna, which is a phase 2 clinical trial of mRNA-1273, which was modified to offer a booster dose of 50 micrograms to 344 people between 6 and 8 months after their second dose. Neutralizing antibody titers began to decline from six months after immunization while with the third dose they significantly rose above the previous efficacy level, thus protecting against severe cases and death. The FDA generally follows the committee’s advice and should rule within a few days, ratifying the decision and thus kicking off the new vaccination campaign.
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These new recommendations come as the nation is seeing a steady decline in coronavirus cases, but has yet to contend with nearly 90,000 new infections and 1,800 deaths a day. The Biden administration has said the third dose will be an important additional tool in the battle against the pandemic, while recognizing that controlling the spread of the disease depends on vaccinating tens of millions of Americans who have not yet received the first dose. A number of no vax and undecided, defined by the president himself, “unacceptably high”.
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