The “chemistry” may not be the only key to countering and fighting the virus Sars-CoV-2. Parallel to the development of drugs and vaccines in laboratories, in fact, scientific journals continue to publish an increasingly substantial body of studies that indicate a new, more “natural” path. A path that is in some ways easier, in the absence of direct side effects, but also more insidious considering the multitude of commercial interests at stake.
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But to the test of science vitamin D, omega-3, lactoferrin, quercetin, vitamin C, zinc, melatonin and glutathione, and activators of sirtuins such as the synergy between pterostilbene, polytadine and onochiol, it seems they can play a decisive role both in the prevention of infection Covid-19 than in contrasting any complications. To clarify the jungle of studies conducted on these compounds and molecules, it was David Della Morte Canosci, professor of Neurology at the University of Miami, of Internal Medicine at the Tor Vergata University of Rome and at the San Raffaele University of Rome.
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In a study published in the journal International Journal of Molecular Sciences and commissioned by Sirt500, the scientist conducted an analysis of all the research on the subject present in the scientific literature. “We decided to investigate the possible antiviral and metabolic effects of these compounds in order to propose a combination of them for potential applications in the prevention and treatment of Covid-19”, He explains Of Death Canosci. “These compounds could be very useful for people who have impaired immune responses, such as people with diabetes mellitus, who we know are more at risk for complications,” he adds.
Finding the right balance between the substances investigated would have two effects: prevention of contagion and mitigation of the effects of the infection. “From our integrated analysis, evaluating the numerous published studies, the strength of the vitamin D and omega-3s in countering the inflammatory process triggered by the infection, reducing the cytokine storm typical of Covid-19”, He explains Of Death Canosci.
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“The activators of sirtuins, such as pterostilbene, polydatin and onochiol, on the other hand seem to have a very powerful antiviral action: through a direct regulation of ACE2 receptors, the gateway Sars-CoV-2 in the cell, they inhibit virus replication, ”he adds. Not only. “These compounds, through the activation of sirtuins, in addition to antagonizing the action of the virus on ACE2 receptors, have a strong antioxidant, anti-inflammatory and anticoagulant power. This would reduce the chances of infection Covid-19 cause that multisystemic pathogenic action such as the lethal formation of microemboli ”. While zinc, vitamin C and melatonin would be able to strengthen the immune system. “This is very important especially for immunosuppressed patients or patients with chronic diseases”.
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Hence the need to use these substances in an integrated and rational way as a preventive approach a Covid-19, pending vaccination. “The first source is certainly an adequate diet – he says Of Death Canosci – and that is why we are developing together with the three-star chef Heinz Beck, a one-of-a-kind food line, created specifically for Palazzo Fiuggi. But you can also evaluate with your doctor the opportunity to integrate with special supplements. There are various proposals on the market, but it is good to make the right choice according to your needs “.
In fact, researchers are testing various combinations of supplements and nutrients. “We are working on a specific protocol that aims to activate specific molecules, sirtuins, which are proteins involved in oxidative stress and inflammation through different processes linked to aging and chronic diseases”, he says. Of Death Canosci. “In collaboration with prof. Camillo Ricordi, at the University of Miami, and in collaboration with important Italian research institutes such as La Sapienza University of Rome, San Raffaele University of Rome, Istituto Superiore di Sanità, our attention – he continues – has focused on the study of selected protective substances integrated in a patented A5 + compound, able to stimulate the natural production of sirtuins, and thanks to this mechanism, to act both in the prevention of chronic diseases typical of aging, and in the protection and prevention of the multisystemic action of viruses “.
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Many possible beneficial effects are still being studied today. “Only rigorous controlled scientific studies will be able to establish with certainty the validity of these protocols,” he concludes Of Death Canosci.
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