Home » Gums and lungs, periodontitis can aggravate chronic obstructive pulmonary disease – breaking latest news

Gums and lungs, periodontitis can aggravate chronic obstructive pulmonary disease – breaking latest news

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Gums and lungs, periodontitis can aggravate chronic obstructive pulmonary disease – breaking latest news

Link Found Between Gum Disease and Chronic Obstructive Pulmonary Disease

A recent study published in mSystems has shed light on the connection between chronic obstructive pulmonary disease (COPD) and gum disease, also known as periodontitis. Researchers from Sichuan University in China have confirmed the link, revealing the role of immune system cells in the progression of the respiratory disease.

Boyu Tang, from the Department of Cardiovascular Surgery at the West China Hospital, explained that periodontitis, which is caused by the accumulation of gingival plaque, is a chronic infectious disease that can be associated with various pathologies, including COPD. Previous studies suggested that the bacterium Porphyromonas gingivalis could play an important role in oral diseases. The new study used murine models to demonstrate how P. gingivalis can aggravate the progression of COPD.

The researchers found that oral bacteria can promote the progression of respiratory disease by activating gamma delta T cells and M2 macrophages of the immune system. In patients with COPD and periodontitis, the activation of γδ T cells leads to increased expression of interleukin 17 (IL17) and interferon gamma (IFNγ), as well as the activation of M2 macrophages.

The study suggests that the optimization of periodontal therapy and the inhibition of γδ T cells and M2 macrophages could contribute to the control of COPD progression. This is the first time that the crucial role of the γδ T-M2 immune mechanism in mediating the progression of COPD promoted by periodontitis has been identified.

These findings align with previous studies in which researchers discovered that P. gingivalis migrated to and infected lung tissue in mice, significantly altering the respiratory tract microbiota. Further observations revealed that periodontitis promotes the expansion of immune cells in lung tissue, leading to the conclusion that P. gingivalis could activate immune cells, promoting the ability to produce cytokines that worsen COPD.

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The researchers plan to conduct further studies on humans to confirm the mechanism. This study has important implications for the management and treatment of both periodontitis and COPD, with the potential to improve the lives of those affected by these chronic diseases.

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