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Here comes the protein that cleans the arteries of the heart

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Here comes the protein that cleans the arteries of the heart

Among the centers involved in the experimental therapy there is also the IRCCS MultiMedica of Sesto San Giovanni which has enrolled its first patient for the trial “ApoA-I Event Reducing in Ischemic Syndromes II (AEGIS-II)”

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To fight a heart attack and prevent relapses comes the “sponge” protein that cleans the arteries of the heart. This is the result of a study, promoted by the Harvard Medical School of Boston, which aims to recruit approximately 20,000 individuals across 1,035 centers around the world, ready to test the “apolipoprotein apoA-I”: a sort of “sponge” capable of absorbing the lipids with which it comes into contact, managing to detach them from the atherosclerotic plaque. Among the centers involved in experimental therapy there is also the IRCCS MultiMedica of Sesto San Giovanni who enrolled his first patient for the “ApoA-I Event Reducing in Ischemic Syndromes II (AEGIS-II)” trial.

“The primary objective of the work – says Dr. Roberto Pedretti, director of the Cardiovascular Department of Irccs MultiMedica – is see if this treatment can reduce the risk of further cardiovascular events in the first 90 days after the heart attack, the period of greatest vulnerability. In Italy – he adds – there are about 130,000 heart attack patients every year and 20% undergo a new event within 12 months “.

“While the existing drugs – explains Professor Giuseppe Ambrosio, coordinator for Italy of the AEGIS-II study and deputy scientific director of Irccs MultiMedica – act by reducing the synthesis of cholesterol and preventing the formation of new accumulations, this therapy has a more ambitious and never achieved before: to attack the plaques already present in the arteries. It is a completely new approach, which we hope – he concludes – will contribute to the reduction of acute events in those who have had a heart attack. The preliminary results are very encouraging “.

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