New nutraceutical formulations based on extracts of orange, lemon e Red grapevine per lower the high blood sugar. This is what researchers are developing AENEAS in the context of Med-Matrix-3 projectfinanced by the nutraceutical company Tighten. Preliminary results show that the treatment of liver cells with some bioactive molecules of citrus fruits e quickly rossa it is able to stimulate their ability to respond to circulating glucose levels. “Specifically, the different plant matrices appear to favor the intracellular uptake of glucose, resulting in a significant increase in glycogen content it’s a improvement dell’insulin resistance“, explains Barbara Benassihead of the ENEA Health and Environment Laboratory and co-author of the study together with her colleague Maria Pierdomenico and Costanza Riccioni, head of Esserre for research and development activities.
How to lower high blood sugar, the hypoglycemic effect of anthocyanins and flavanones
The research team studied insulin resistance using human liver cells treated with the natural extracts to verify the hypoglycemic effect Of anthocyanins e flavanonesbeneficial molecules of which red vine and citrus fruits are very rich.
L’insulin resistance it is a pathological state in which target cells, in particular liver, muscle and adipose tissue, do not respond to normal levels of circulating insulin, with consequent alteration of glucose and lipid balance (homeostasis). “In terms of mechanism of action, it is often caused by the malfunctioning of the insulin receptor IRS-1; therefore, acting on this molecule through an innovative nutraceutical formulation could significantly contribute to the improvement of insulin resistance”, concludes the ENEA researcher.
If further validated, these experimental results would pave the way for the use of formulations based on flavonoids obtained from lemon, orange and red vine extracts such as nutraceuticals for the control of blood sugar and for the treatment of insulin resistance in subjects at risk or who experience serious side effects associated with the intake of conventional hypoglycemic drugs.
 In humans, glycogen serves as a carbohydrate energy reserve. It is deposited mainly in the liver and skeletal muscle; however, it is also present in other tissues, including the heart, kidneys, and adipose tissue
 That is, reducing glucose levels by acting positively on insulin resistance
 Hesperidin and eriocitrin
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