Home » I hope to beat ALS with a drug already used for bronchial asthma: an Italian research

I hope to beat ALS with a drug already used for bronchial asthma: an Italian research

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I hope to beat ALS with a drug already used for bronchial asthma: an Italian research

New hopes towards ALS from anti-asthma drug

In a breakthrough research performed by Italian researchers, there may be new hope within the battle towards Amyotrophic Lateral Sclerosis (ALS) with using an anti-asthma drug, montelukast. The research, named “GPR17ALS-1,” was led by Marta Fumagalli, an affiliate professor of Pharmacology on the University of Milan, and Tiziana Bonifacino, a researcher on the Department of Pharmacy on the University of Genoa, in collaboration with AriSla – Italian analysis basis for ALS.

ALS is a neurodegenerative illness that impacts motor neurons, inflicting progressive paralysis of voluntary muscle tissue. Until now, there have been no efficient remedies to counter the development of the illness. However, the current research printed within the British Journal of Pharmacology exhibits promising leads to utilizing montelukast to probably decelerate the illness’s development.

The research performed experiments in mice with ALS and located that montelukast administration led to vital enhancements in survival and motor efficiency in feminine mouse fashions. This discovering means that montelukast may probably delay the course of the illness in people as properly.

Maria Pia Abbracchio, head of the Laboratory of Cellular and Molecular Pharmacology of Purinergic Transmission at UniMi, highlighted the protecting perform of montelukast towards different sorts of neurodegenerative ailments based mostly on earlier research. The researchers additionally investigated the molecular mechanisms underlying the protecting results of montelukast in feminine mouse fashions with ALS.

The outcomes of the research are encouraging researchers to additional discover the effectiveness of montelukast in human experimental fashions of ALS. This personalised method may assist perceive particular person mechanisms of the illness’s development and drug response, probably resulting in more practical remedies sooner or later.

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AriSla expressed its satisfaction with the research’s thrilling outcomes, noting the prime quality of analysis supported by the muse. Since 2008, AriSla has been dedicated to supporting analysis to determine efficient options for treating ALS sufferers. This new research presents a glimmer of hope within the battle towards ALS and brings us one step nearer to discovering a treatment for this devastating illness.

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