Vaccine universal against the‘influenza successfully tested on animals. A protective result against several variants of virus flu, both influenza A and influenza B. The study was conducted at Georgia State University and published in the journal PLOS Pathogens.
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Influenza viruses tend to mutate rapidly, so much so that every season the vaccine is updated based on an estimate of the new circulating strains. To make a universal vaccine, ie valid on different strains, it is necessary to use a viral protein portion equal in all strains as the «active ingredient» (antigen). Experts worked on a vaccine based on conserved portions of viral proteins known to activate the immune system – protein domains that occur the same in all major influenza strains.
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Researchers tested the vaccine on mice demonstrating its protective efficacy against seasonal variants of influenza A and potentially pandemic virus variants (H1N1, H5N1, H3N2, H9N2 and H7N9) and again against influenza B variants ( Yamagata and Victoria). ‘We have developed a single universal vaccine that induces immunity against conserved domains of viral proteins; we have demonstrated its efficacy against various influenza A and B viruses in both young and old mice ”- explained Sang-Moo Kang, coordinator of the work.
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The study supports a new strategy to create a universal influenza vaccine, a single construct based on several viral protein fragments, which has the ability to produce immunity and offer broad-spectrum protection against severe disease and death. The next step will be to test the vaccine on ferrets that have a respiratory system more similar to ours, the authors concluded.
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Last updated: Friday 26 August 2022, 10:12
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