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Light on the human heart’s potential to self-repair and regenerate. « Medicine in the Library

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Light on the human heart’s potential to self-repair and regenerate.  « Medicine in the Library

Light on the human heart’s potential to self-repair and regenerate.

Posted by giorgiobertin on February 16, 2024

An innovative scientific study published in “Nature Cardiovascular Research” by the researchers of Texas Heart Institute has unveiled an extraordinary discovery that could have far-reaching implications for the treatment of heart disease.

A heart attack is known to cause irreparable damage to heart muscle cells. Although current treatments focus on relieving symptoms and improving blood flow, they fail to address the crucial problem of lost cardiomyocytes (CMs), which lead to further complications such as heart failure.

Study reveals that cardiomyocyte (CM) regeneration requires a complex microenvironment, where a dynamic synergy between CM, resident immune cells, and cardiac fibroblasts is the driving force of cardiac renewal. Through complex signaling mechanisms, these cell types instruct and support each other in a coordinated manner, facilitating CM proliferation and effectively repairing damaged cardiac tissue.

The team said understanding heart regeneration at the molecular level is critical to developing innovative therapies. Their study challenges the existing paradigm, suggesting that targeting the microenvironment is instrumental in healing the wounded heart.

Read the full text of the article:
YAP induces a neonatal-like pro-renewal niche in the adult heart.
Li, RG, Li, X., Morikawa, Y. et al.
Nat Cardiovasc Res (2024).

Source: Texas Heart Institute

This entry was posted on febbraio 16, 2024 a 6:06 am and is filed under News-research. Tagged: biology, cardiology, regenerative medicine. You can follow any responses to this entry through the RSS 2.0 feed.

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