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Nanoparticles illuminate cancer biomarkers and guide surgery. « Medicine in the Library

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Nanoparticles illuminate cancer biomarkers and guide surgery.  « Medicine in the Library

Nanoparticles illuminate cancer biomarkers and guide surgery.

Posted by giorgiobertin on June 6, 2023

Cancer surgeons may soon get a more complete view of tumors during surgery thanks to new imaging agents that can illuminate multiple biomarkers simultaneously, report researchers at theUniversity of Illinois Urbana-Champaign.

The fluorescent nanoparticles, wrapped in red blood cell membranes, target tumors better than current clinically approved dyes and can emit two distinct signals in response to a single beam of surgical light, a feature that could help doctors distinguish the boundaries of the tumor and identify metastatic tumors.

One wavelength of laser light during surgery elicits two distinct signals from the membrane-wrapped nanoparticles, one color for each of the two biomarkers that the nanoparticles target. One is common in earlier stages of cancer, and the other indicates later-stage – and possibly metastatic – cancer.
Image by Ella Maru Studios

The two biomarkers targeted by the new imaging agents include one that is prevalent in early-stage cancer and one that is prevalent in late-stage cancer, which is more likely to be metastatic. The researchers, as described in the journal “ACS Nano“, found that the probes were effective in distinguishing cancerous tissue from healthy tissue, as well as distinguishing the two signals from each other.

The researchers plan to develop more tumor imaging agents that target more markers and move forward with additional preclinical and clinical studies using their dual-signal dyes with surgical goggles they have already developed.

Read the full text of the article:
Cell-membrane coated nanoparticles for tumor delineation and qualitative estimation of cancer biomarkers at single wavelength excitation in murine and phantom models.
Srivastava I, Lew B, Wang Y, et al.
ACS Nano. 2023;17(9):8465-8482. doi: 10.1021/acsnano.3c00578

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Source: University of Illinois Urbana-Champaign

This entry was posted on giugno 6, 2023 a 4:54 PM and is filed under News-search, Techno-Health. Marked by tags: biochemistry, biotechnology, surgery, Medicine Laboratory, oncology. You can follow any responses to this entry through the RSS 2.0 feed.

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