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the 8 signs that appear 18 years before the symptoms |

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the 8 signs that appear 18 years before the symptoms |

When Alzheimer’s begins to develop? Research supports that it is born at least 18 years before the manifestation of its symptoms.

This, in a nutshell, is the result of a study by the Innovation Center for Neurological Disorders at Xuanwu Hospital in China. The researchers discovered eight specific signals to watch out for and which appear years before the manifestation of the neurological disease. You can read the results in the prestigious scientific journal The New England Journal of Medicine.

When Alzheimer’s begins to develop: Chinese research

The researchers analyzed data from thousands of people, both men and women, with an average age of 61, all healthy at the start of the research, monitored throughout the study China Cognition and Aging Study (COAST) performed between January 2000 and December 2020.

The volunteers were subjected to regular exams for twenty years. Among the tests followed, that of the cerebrospinal fluid (CSF), as well as brain scans and evaluation of cognitive function through standardized tests like the Clinical Dementia Rating-Sum of Boxes (CDR-SB).

What are the eight signs to watch out for when Alzheimer’s begins to develop

The working group compared the participants’ data, discovering that there are eight signs that confirm that Alzheimer’s is developing in the brain:

increased concentration of beta-amyloid protein 42 in the cerebrospinal fluid already 18 years old before the onset of the disease. The accumulation of beta amyloid is considered among the main signs of Alzheimer’salthough we do not find it in all patients.
Difference in the ratio between beta-amyloid 42 and beta-amyloid 40 Already 14 years earlier. These are two forms of proteins, the accumulation of which in the nervous system is linked to neurodegeneration.
Increased phosphorylated tau 181 protein 11 years earlier of the debut. TO 10 years from the onset of symptoms, it is noticeable an increase in tau.
I the first neuronal damage occurs nine years after onset. The first to have problems are the axons, i.e. the extensions of the neurons, the brain cells, essential for the transmission of the electrical impulse. Already at 8 years old from the onset, the MRIs show thehippocampal atrophy, the area of ​​the brain involved in cognition. THE Standard tests for evaluating dementia confirm cognitive decline as early as six years from the onset of symptoms. There is the greatest possibility for Alzheimer’s patients of have a genetic variant called APOE4already demonstrated by other studies.

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Alzheimer’s numbers in Italy

In Italy approximately 1,200,000 people live with a form of dementia. Just over half of them have Alzheimer’s. There are also 900,000 people who have a minor neurocognitive disorder (Mild cognitive impairment) that could become Alzheimer’s. The data comes fromDementia Observatory of the Istituto Superiore di Sanità. Women get Alzheimer’s disease about twice as often as men. The leading hypothesis is that women have more tau protein in their brains.

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