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There is the thirty signature on the anti Covid drug – Health and Wellness

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TRENTO. The hope is that it is the turning point: there could be a drug that can cure the most serious forms of Covid. And the signature, the commitment at the forefront, the fundamental help in research also comes from Trentino. The infectious disease specialist Andrea Angheben, head of the department of the Department of Infectious and Tropical Diseases of the Negrar hospital in Verona, was in fact born in Rovereto.

An international study, in which the Trentino doctor also participated, said that the biological drug “anakinra” drastically reduces hospitalization in intensive care and deaths from severe respiratory failure.

“The results are particularly exciting – says the doctor satisfied -, I was able to personally see that some patients clinically destined to be intubated showed a rapid and unexpected improvement a few hours after the administration of the experimental drug”.

The study was conducted on 594 patients hospitalized for pneumonia and sees as principal investigator Evangelos J. Giamarellos-Bourboulis, a professor at the University of Athens, who coordinated 37 hospitals, including 8 Italians in turn coordinated by the Spallanzani Institute in Rome. Negrar’s “Sacro Cuore Don Calabria” is one of the centers in Italy that has enrolled the largest number of patients (15).

«The study showed that the early administration of anakinra it reduces mortality by 55% and the risk of death or the need for hospitalization in intensive care by 64% for the progression of pneumonia into severe respiratory failure assessed on the 28th day », continues Dr. Angheben, who has personally followed the research.

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“While being in the dark about who received the drug compared to placebo, I was able to personally see that some patients clinically destined for hospitalization in intensive care showed a rapid and unexpected improvement within hours of administering the experimental drug”.

The “miracle medicine”, so far used mainly for the treatment of rheumatoid arthritis, has been shown to be able to drastically reduce the worsening of Covid.

The results of the “Save more” trial (technically: Phase III, randomized and double-blind) have been published in the prestigious journal Nature Medicine and the EMA (European Medicines Agency) has started the evaluation process to extend the indications of the ‘anakinra at Covid-19.

«We know that the greatest damage caused by Covid – adds the doctor from Trentino – is due to the inflammation (the“ famous cytokine storm ”) that paradoxically causes our immune system by reacting in an uncontrolled manner to the virus. Inflammation is an interleukin-mediated process. In fact, since the onset of Covid, a lot of research has been born on inflammation inhibiting drugs, such as tocilizumab currently indicated in the treatment of the virus. The anakinra acts on a very important interleukin, 1-alpha and 1-beta, blocking it and therefore stopping the inflammatory cascade ».

A fundamental characteristic, the latter, «because the reduction of inflammation also involves the reduction of the immune response and therefore exposes the person already suffering from pneumonia or intubated to superinfections. This can happen with other similar drugs, such as tocilizumab. In fact, the study did not detect more infections in those who took the drug, compared to patients in the placebo control arm. We are therefore faced with a drug that is not only effective but also safe ».

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But anakinra would not be as effective if it were not administered at the right time.

«The clinic taught us from the beginning that inflammation can only be countered by promptly administering the drugs we had, primarily cortisone. Thanks to this study, we now know how to quantify the adverb “promptly” ».

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