It has been and is a major concern, especially in parents of teenage children or young boys. The cases of myocarditis, in fact. But most cases of suspected Covid-19 vaccine-related myocarditis in young people have a calm clinical course, with mild symptoms. The latest data collected on the issue in a study published in Circulation and coordinated by Dongngan T. Truong, of the University of Utah in Salt Lake City. 139 adolescents (mean age 15.8 years) with 140 episodes of suspected myocarditis (49 confirmed and 91 probable) developed within one month of m-RNA vaccine were studied in different centers between the USA and Canada.
Myocarditis and pericarditis, you risk much more with Covid than with the vaccine
The most common symptom was chest pain: over four out of five young people were treated with non-steroidal anti-inflammatory drugs. Overall, the average hospital stay after the eventual admission was two days. The study represents a further piece in a mosaic of information that is being drawn on the risks of myocarditis in young people vaccinated for Sars-CoV-2 with messenger RNA vaccines (i.e. Pfizer and Moderna): in the face of a higher probability of developing myocarditis compared to the general population (but still very low compared to the risk of heart disease after Covid-19), cardiologists still remember that the risk-benefit ratio is very much in favor of vaccination, even in this age group. This was reported by the experts present at the congress of the Italian Society of Cardiology (Sic) underway in Rome. Ciro Indolfi, Sic president, reminds us in this sense that “although there was a slightly higher risk in young subjects under the age of 30 (about 15 cases out of 100,000), the cases of myocarditis were mild and rapidly resolved in 95% of cases. we know that myocarditis mainly affects young men, particularly around the age of 15 “.
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The cdc (Centers for Disease Control) in Atlanta estimates that the risk of myocarditis after vaccination with m-RNA is 70 per 1 million doses administered among boys aged 16 to 17, which therefore appears to represent the range at higher risk, while it would be almost negligible among girls and the elderly. For this reason, we must continue to carry out careful monitoring and collect information, as also emerges from a research conducted in Israel some time ago, published in New England Journal of MedicinAnd. The study, coordinated by Tel Aviv University, evaluated the onset, presentation, clinical course and outcome of myocarditis after at least one dose of Pfizer-Biontech’s messenger RNA vaccine. Out of more than 2.5 million vaccinated individuals aged 16 years and older, 54 cases met the criteria for myocarditis. The estimated incidence for people who received at least one dose of the vaccine was 2.13 cases per 100,000 cases This incidence of myocarditis is increased to 10.69 cases per 100,000 people in male patients aged 16 to 29 years, thus confirming that in this population it is necessary to carefully monitor the situation.
Covid vaccine and myocarditis risk: slightly rises with the second dose but 8 out of 10 cases are mild
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“Pharmacovigilance has a fundamental role and health authorities will continue to monitor the safety and efficacy of vaccines with the progressive increase of the administrations in adolescents and young adults while remaining alert to detect signs and symptoms of myocarditis and pericarditis, such as, among more common, chest pain, changes in the electrocardiographic trace and the alteration of some blood tests, such as the troponin measurement “, continues Indolfi. On the risk-benefit ratio, then, it must be said that it has been shown that myocarditis linked to the systemic inflammatory state can be a complication of Covid itself, with much worse outcomes and weight: in fact it has an incidence almost four times higher than that observed. in vaccinated subjects, for which vaccination remains useful to avoid the complications of Covid and protect the individual and society. “Myocarditis after vaccinations for Covid-19 are rare events and in the vast majority of cases have a low-risk clinical presentation and generally a very favorable prognosis – he concludes. Gianfranco Sinagra, Professor of Cardiology at the University of Trieste and Vice President Sic. Further studies will be useful for understanding the possible mechanisms underlying myocardial episodes, but currently vaccinating remains essential to first of all preserve health but also guarantee freedom, growth and development “.
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