I single, il sex, women. Not only previous diseases, but also age, marital status and lifestyles affect the immune response that is acquired after the anti Covid-19 vaccination. To say it is an Italian research, promoted by Sapienza and from the Polyclinic Umberto I of Rome and published in the Journal of Personalized Medicine. The study examined 2,065 health workers of the Policlinico Umberto I who had been administered the vaccine anti-Covid-19 mRNA from Pfizer BioNTech.
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The sample was subjected to two blood draws, after 1 month and 5 months after the second vaccination. The results showed that one month after vaccination, subjects with a previous Covid-19 infection and younger ones had higher antibody levels. In contrast, autoimmune diseases, chronic lung diseases, and smoking were correlated with lower levels. A median decrease of 72% in the antibody level was observed 5 months after vaccination, but this is less evident in donne and in subjects with previous infection. On the other hand, in smokers, hypertensive and older people, a drop of about 82% in anti-Spike antibody levels was found.
The researchers also revealed a greater maintenance of antibody response in single or cohabiting subjects compared to married, divorced or widowed subjects, “although this association could be due to other unexplored clinical variables, such as dietary style and body mass index. », Underline the researchers.
THE RESULTS – The results showed that, one month after vaccination, subjects with a previous Covid-19 infection and younger ones have higher antibody levels than others. In contrast, autoimmune diseases, chronic lung diseases, and smoking are related to lower levels of antibody responses. A median decrease of 72% in the antibody level was observed 5 months after vaccination, but this is less evident in women and in subjects with previous infection. On the other hand, in smokers, hypertensive people and the less young, a dramatic drop of about 82% in anti-Spike antibody levels was found. There was also evidence of a higher maintenance of the antibody response in single or cohabiting than in married, divorced or widowed subjects, although this association could be due to other unexplored clinical variables, such as dietary style and body mass index.
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“The study – comments the director of Sapienza Antonella Polimeni, one of the authors of the research – highlights how the pursuit of salute, even in the face of pandemic situations, underlies a more general principle of social well-being. In fact, lifestyle factors play an important role in the immune response. The first cure is therefore the raising of the health culture and the quality of life standards ». “The results of this work, which once again underline the importance of lifestyles – declares Fabrizio d’Alba, general manager of the Policlinico Umberto I – always make us confident of the validity of the path taken by Sapienza and Umberto I. A path common with a view to synergistic exchange that will make our scientific community stronger “. «The study – explains Domenico Alvaro, dean of the Faculty of Medicine and Dentistry – is a demonstration of how the company and the university are in absolute harmony also in research, and in particular in sectors so relevant to public health. Furthermore, the wide participation of health personnel demonstrates the sense of responsibility to achieve results which, also in relation to Covid-19, represent a further stimulus to pursue healthy lifestyles “.