Home » The ISS on children’s hepatitis: four cases ascertained in Italy, adenovirus unlikely

The ISS on children’s hepatitis: four cases ascertained in Italy, adenovirus unlikely

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The ISS on children’s hepatitis: four cases ascertained in Italy, adenovirus unlikely

Four cases in Italy of acute hepatitis in children. This is the data, referred to April 20, provided by the Istituto Superiore di Sanità, which on its portal has published a fact sheet on pediatric hepatitis of unknown origin on which scientists are questioning. “On April 5, 2022 – recalls the ISS – the United Kingdom notified an increase in the number of cases of hepatitis in previously healthy children under the age of 10. On April 12, the United Kingdom reported that, in addition to the cases reported in Scotland, around 61 cases under investigation had been identified in England, Wales and Northern Ireland, most between the ages of 2 and 5. On April 14, Scotland reported 13 cases under investigation including two couples with epidemiological links “.

As of April 21, cases in children “have been reported in Belgium, Denmark, France, Ireland, the Netherlands, Romania, Spain, potentially in Sweden, on April 19 in Israel (12 cases) and on April 20 in Italy (4 cases). Most countries report a limited number of cases, with the exception of the United Kingdom which, as of 21 April 2022, had identified over 100 children under 10 years of age with acute hepatitis of ndd in total 8 children received a liver transplant “. Outside the European Union, “as of April 15, 9 cases of acute hepatitis of ndd among children aged 1 – 6 years with a positive test for adenovirus have been reported by the health authorities of the US state of Alabama, some of them had adenovirus infection serotype 41 “.

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“At the moment – the ECDC reports in the latest bulletin updated on 23 April – there is no clear correlation between the reported cases. No clear epidemiological risk factor emerged between the cases, as well as no association with travel”.

ECDC: “WE INVESTIGATE THE LOCKDOWN EFFECT”

“Investigations right now point to a link to adenovirus infection.” As to why reports of acute hepatitis of unknown origin in previously healthy children are now emerging we have “all speculation”. The argument that there has been “little exposure in the past two years due to lockdowns and little interaction” between the children “may be a factor, but I can neither confirm nor deny it as it is still under investigation at this time.” It was to underline it Andrea Ammondirector of the European Center for Disease Prevention and Control (Ecdc).

Ammon explained that “the most common clinical presentation was jaundice, then yellowing in the skin and eyes, followed by vomiting and gastrointestinal symptoms that are compatible with the adenovirus that some investigations point to, but then some of these. children had more severe symptoms and very acute liver failure which required emergency liver transplants. “

SILERI: IN ITALY 3 CONFIRMED CASES

In Italy we have about ten reports, a transplant has been done and three cases are confirmed “but” be careful to think that every case of hepatitis in children is of unknown origin, because even if rare, this disease was there even before “. Thus, on Radio InBlu2000, the Undersecretary of Health Pierpaolo Sileriwho added: “the suspected cases of acute hepatitis will probably be overestimated compared to the real ones. Attention therefore to the flourishing of reports but then many will be removed from the final calculation”.

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ANDREONI: NEW VIRUS NOT EXCLUDED

On cases of acute hepatitis of unknown origin “we remind you that we are faced with few reports in the world, so attention is needed and we need to communicate any other suspected cases without creating an unmotivated panic in the population. We await the results of science, investigations can be laborious and complicated, at the moment we cannot even exclude that we are facing a new virus that may have modified the child’s acute hepatitis “. Like this Massimo Andreonihead of infectious disease at the Tor Vergata Polyclinic in Rome and scientific director of the Italian Society of Infectious and Tropical Diseases (Simit).

Andreoni reconstructs the scenario. “There are usually cryptic hepatitis of unknown etiology and specialists move on several fronts: the viral origin, the food toxic one or even the autoimmune origin – he specifies – Made this distinction, in the cases of viral hepatitis of unknown origin registered up to now in the world, we can exclude the scenario of food origin because we do not have a family cluster or restricted to a city, but several cases scattered around the world. Even on the hypothesis that there may be an immunological or autoimmune origin, the number of cases exceeds that expected – observes the infectious disease specialist – The infectious origin remains but it must be demonstrated, especially the one that focuses on adenovirus, given that not in all cases confirmed today there is the presence of adenovirus. also the possibility, difficult however, that there may be a mutated adenovirus behind it “.

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“Meningitis causes much more damage and deaths around the world than these cases of acute hepatitis in children, but since we know it we worry less. This, however, makes us understand that we need, first of all, to understand which infectious agent is responsible for the cases. Finally – suggests Andreoni – if there are some symptoms such as vomiting, fever, abdominal pain or yellow eyes, we must call the pediatrician. activate the necessary checks “.

HOPE: THE PEDIATRICIAN NETWORK IS CENTRAL

“I met the representatives of the Italian Federation of Pediatricians this morning. Their proximity network is essential to protect the health of the little ones and assist their families. In these days they are also busy monitoring any cases of acute hepatitis in children. L ‘Italy can count on their passion and their great professionalism at all times “. The Minister of Health states on Fb, Roberto Speranza.

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