Rome, 9 July 2021 – They have been 27 “adverse reactions” to heterologous vaccination anti Covid, i.e. referring to a mixed cycle of vaccines (as in the case of those under 60 who received AstraZeneca as the first dose, and another serum from Pfizer or Moderna as a second), on 233,034 administrations. TheItalian Medicines Agency (Aifa) in the sixth Pharmacovigilance Report on Covid-19 Vaccines, reporting the reports of the period between 27 December 2020 and 26 June.
Summary
“In relation to the so-called heterologous vaccinations to persons under 60 years of age they had received Vaxzevria 27 reports were entered as the first dose, out of a total of 233,034 administrations (the second dose concerned in 86% of cases Comirnaty di Pfizer and in 14% Spikevax by Moderna), with a reporting rate of 12 per 100,000 doses administered “.
In total, that is, even those who did not receive the mix but followed the cycle with the same vaccine, have been 76,206 reports of “adverse events” after administration with the 4 sera used in the vaccination campaign underway in Italy. “Out of a total of 49,512,799 doses, 87.9% reported non-serious events, such as injection site pain, fever, asthenia, fatigue and muscle aches. The reporting rate is 154 per 100,000 doses.” , reads the AIFA report.
“The serious reports correspond 11.9% of the total, with a rate of 18 serious events per 100 thousand doses administered, regardless of the type of vaccine, the dose (first or second) and the possible causal role of vaccination “, explains the report of the Italian drug agency.
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Furthermore, it is noted that “the reaction occurred in most cases (about 80%) on the same day as the vaccination or the following day and only more rarely beyond the following 48 hours “.
The highest number of reports came from Pfizer / BioNTech’s “Comirnaty vaccine (69%)”, so far the most used in the vaccination campaign (70.6% of the doses administered), recalls Aifa, emphasizing instead that the reports “only to a lesser extent” concerned AstraZeneca’s Vaxzevria vaccine (24.7% of reports and 17.3% of administered doses) “. Moderna’s Spikevax vaccine has 5.2% of reports and 9.6% of administered doses, and Johnson & Johnson’s Janssen 1.1% of reports and 2.5% of administered doses.
The most reported so-called “adverse events” are fever, fatigue, headache, muscle or joint pain, injection site pain, chills and nausea. The most frequently reported severe ones show a clinical picture of “flu-like syndrome with intense symptoms, more frequent after the second dose of mRna vaccines and after the first dose of Vaxzevria”.
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