Milan, 27 May 2021 – Unveiling the cause of the rare cases of thrombosis after vaccination, e suggest how to avoid them this is what the study of teams of German scientists is proposing. The job is that Rolf Marschalek, Professor at the Goethe University of Frankfurt, who with his collaborators conducted investigations on this type of problem recorded after the administration of some sera.
Coronavirus Bulletin of May 27
The working group thinks they have unraveled the mechanism behind the rare blood clots which have been reported after Covid vaccinations with Oxford/AstraZeneca e Johnson & Johnson, reads the Financial Times.
The problem would lie in the adenoviral vectors that both vaccines, AstraZeneca and Johnson & Johnson, use to provide the genetic instructions for the production of the Sars-Cov-2 Spike protein in the body, which will then allow an immune response to develop.
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The hypothesis is that these vaccines work sending the genetic sequences into the cell nucleus, arriving at the intracellular fluid (cytosol) that is inside the cell where the virus normally produces proteins: inside the cell nucleus, some parts of the DNA of the Spike protein are joined or separated, creating mutant versions, which are unable to bind to the cell membrane where important immunization occurs. The floating mutant proteins are then secreted by cells in the body (the phenomenon described is called ‘splicing’), triggering blood clots in about one in 100,000 people.
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Instead the mRna vaccines they supply Spike’s genetic material to cell fluid but never enter the nucleus.
Professor Marschalek then proposes a “way out” of the risk: if the vaccine developers modify the gene sequence that codes for the spike protein to avoid ‘splicing’. J&J would already have Marschalek to ask for information.
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