What happens to our body after the age of 70 and what makes it age? A new study would finally find out why our bodies become more fragile and what causes it to age.
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Being born, growing up, getting old is the path already written for everyone, but what happens to our body after the age of 70 and what makes it grow old? A new study would finally find out why our bodies become more fragile and what causes it to age.
The starting assumption is that increasing age causes in human hematopoiesis (production of cells in the blood) a reduced regenerative capacity, cytopenias and immune dysfunctions.
This increases the risk of blood cancers, anemia and compromises the effectiveness of white blood cells in fighting infections.
According to the study, such changes could be why people often age healthily for decades before experiencing a more rapid decline in their 70s to 80s.
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I study
Researchers from the Wellcome-MRC Cambridge Stem Cell Institute studied the sequences of 3,579 cells single cell-derived hematopoietics in 10 subjects in all age groups, from infants to people between 70 and 80 years of age.
What would emerge mainly was that adults under 65 had a wide range of red and white blood cells produced by different types of stem cells in their bone marrow.
While, the over 65 presented a totally different picture. In fact, half of their blood cells came from 10 or 20 distinct stem cells, dramatically reducing the diversity of blood cells, with consequences for their health.
The exponential increase of stamina cells in subjects over 65 it would thus explain the aging process and the weakening. This is because the sudden growth of stem cells in the body is linked to blood cancers and anemia and makes people less resistant to infections and medical treatments such as chemotherapy.
Furthermore, it was found that factors such as chronic inflammation, smoking, infection and chemotherapy could produce more stem cells with cancerous mutations.
It remains only to find out if and what factors could slow the aging process and understand how the newly discovered mutations affect blood function in the elderly, so that we can learn how to minimize the risk of disease and promote healthy aging.
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Source: nature.com
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