Never before in the past two years have we evoked and invoked our immune system so often and so passionately. We counted on him to hope to dodge the new viral challenges and be among the few who managed to save themselves from the contagion of the new Coronavirus. Well, now it turns out that to enhance our natural defenses we also have a new ally: brewer’s yeast.
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Il Saccharomices Cerevisiae, commonly known as “brewer’s yeast”, can in fact modulate the immune system and promote both immunostimulating and anti-inflammatory actions. The novelty stems from a research carried out by the Molecular Neuroimmunology laboratory of the neurorehabilitation hospital and neuroscience research institute Santa Lucia IRCCS Foundation in Rome.
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Il Saccharomices Cerevisiae it is the yeast responsible for alcoholic fermentation and is the most important in human nutrition. Used since ancient times for bread making, the production of beer and wine, it is one of the most studied microorganisms in the field of microbiology, but still reserves some surprises.
The research team of the Santa Lucia IRCCS molecular neuroimmunology laboratory, led by the biologist and neuroimmunologist Elisabetta Volpein collaboration with the neuroimmunology laboratory of the Santa Lucia IRCCS and the University of Florence, studied the interaction between brewer’s yeast and the cells of the immune system, evaluating the activation of dendritic cells, the first to come into contact with the microorganisms that make up the intestinal bacterial flora including brewer’s yeast, which is introduced with food and lives in symbiosis with our organism.
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The researchers’ discovery is that the action of yeast on the immune system, hitherto believed to be neutral, is the result of two simultaneous activations. At the mucosal level, yeast wall components activate inflammatory myeloid dendritic cells, while yeast DNA and RNA activate anti-inflammatory plasmacytoid dendritic cells. Under normal conditions these two actions balance each other ensuring the balance of the intestinal microbiota, but in certain pathological conditions they can play a role, for example in chronic inflammatory conditions.
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“Since we ingest a large amount of this yeast every day through food” explains Elisabetta Volpe “we wondered about its effects on the immune system, responsible for the balance of the intestinal microbiota. From the point of view of neuroscience it is very important to evaluate the elements disturbance of the intestinal microbiota because dysbiosis, ie the loss of balance between the different populations of bacteria, fungi and viruses that make up the intestinal flora, can contribute to neurological and autoimmune diseases “.
The study published in the scientific journal Frontiers in Immunology offers important therapeutic perspectives: comments the biologist Andrea Sabatinifirst signature of the study: “On the one hand the administration of probiotic based on the components of the yeast cell wall could be used as immunostimulating therapy, on the other hand the administration of probiotic based on yeast nucleic acids could enhance the anti-inflammatory response in chronic inflammatory diseases “.
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The study was carried out within the basic research activity in the field of neuroscience carried out by the Institute of Hospitalization and Scientific Care of the Santa Lucia Foundation in Rome. Based on this study, the team of researchers is gathering new experimental evidence to evaluate the potential use of the anti-inflammatory properties of brewer’s yeast nucleic acids in specific autoimmune diseases such as multiple sclerosis and Crohn’s disease.