Nanoparticles stimulate the immune system against cancer.
Posted by giorgiobertin on March 23, 2024
A nanoparticle-based therapy developed by scientists atUT Southwestern Medical Center stimulated an immune pathway that eradicated tumors in mouse models of various cancers.
This illustration depicts a nanoparticle (purple) activating the stimulator of interferon genes (STING) proteins (yellow) in dendritic cells to recruit cytotoxic T cells into an immune “cold” tumor.
This new nanoparticle-based therapy takes a different approach: activating a molecule known as an interferon gene stimulator (STING). This anciently evolved molecule responds to a molecular signal called cGAMP. Generated when cells sense an infection or cancer, cGAMP signals immune cells to prepare for battle.
Activating STING to fight cancer is not a new concept, but molecules developed to target STING have been largely ineffective for various reasons. However, Dr. Gao’s team has created a new experimental therapy that incorporates cGAMP into PC7A nanoparticles, achieving promising results in mouse models of various types of cancer.
Read abstract of the article:
STING licensing of type I dendritic cells potentiates antitumor immunity.
Jian Wang et al.,
Sci. Immunol.9, eadj3945(2024). DOI:10.1126/sciimmunol.adj3945
Source: UT Southwestern Medical Center
This entry was posted on marzo 23, 2024 a 6:10 am and is filed under News-research. Tagged: biotechnology, immunology, oncology. You can follow any responses to this entry through the RSS 2.0 feed.
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