A molecular mechanism inhibits the immune response
Glioblastoma is the most aggressive form of brain tumor in adults and the therapeutic options available today are very limited. The marked hypoxia (lack of oxygen) and immunosuppression that characterize the microenvironment of this tumor make even the most recent immunotherapy strategies ineffective.
A new study published in the journal Immunity, the result of collaboration between researchers at the Moffitt Cancer Center in Tampa, Florida, coordinated by Filippo Veglia, and researchers at the Department of Experimental Medicine of the Sapienza University of Rome, coordinated by Aurelia Rughetti, has identified a subpopulation of immune cells, macrophages, characterized by high levels of the glucose receptor (GLUT1) which show a marked immunosuppressive capacity, capable of inhibiting the immune response and promoting the progression of … (Continue) read the 2nd page
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