09.05.2024 – 09:00
University of Montpellier
Montpellier, France (ots/PRNewswire)
It wasn’t the supposedly dead brain tissue!
The international IN EXTREMIS-LASTE study, coordinated by Montpellier University Hospital in France, represents a groundbreaking contribution to stroke research and was published today in the New England Journal of Medicine.
“LASTE” (LArge Stroke Therapy Evaluation), a prospective, randomized, controlled study led by Prof. Vincent Costalat (neuroradiologist, Montpellier, France) and Dr. Caroline Arquizan (vascular neurologist, Montpellier, France) and Dr. Bertrand Lapergue (vascular neurologist, Hôpital Foch, Paris, France) and Prof. Tudor Jovin (interventional and vascular neurologist, Cooper University Hospital, Camden, USA) has the potential to revolutionize the current treatment of patients with acute stroke due to large vessel occlusion by It shows that even patients with the largest “irreversibly” damaged brain areas, who have been examined using the most modern imaging techniques, benefit from mechanical reperfusion.
Trial of Thrombectomy for Stroke with a Large Infract of Unrestrited Size, veröffentlicht im New England Journal of Medicine https://www.nejm.org/
Since mechanical thrombectomy, a procedure to restore blood flow in stroke patients with a sudden blockage of a cerebral artery by removing the blockage using device-assisted technology, became standard treatment in 2015, doctors have selected only stroke patients with limited brain damage that could be detected on imaging tests. This was based on the assumption that restoring blood flow to large areas of irreversibly damaged brain is not only useless but may actually cause additional damage, including an increased risk of cerebral hemorrhage and other deleterious effects of reperfusion.
An international network of stroke centers led by Montpellier University Hospital has proven otherwise. The multicenter therapy study “LASTE” was carried out in France (26 centers) and Spain (7 centers) over a period of 3 years. The aim of the study was to select patients who were diagnosed with a large vessel occlusion within 7 hours of the onset of stroke were classified as “lost” to test the hypothesis that reperfusion of thought-to-be-dead brain tissue could improve not only survival but also functional recovery.
IN EXTREMIS TRIALS LASTE and MOSTE are supported by an unrestricted industry grant co-financed by 5 industry partners (BALT, CERENOVUS, MEDTRONIC, MICROVENTION, STRYKER).
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Original content from: CHU de Montpellier, transmitted by news aktuell