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Love is not just a matter of the heart. Indeed science tells us that the brain plays a role that is by no means secondary both in falling in love and in sexual pleasure and also in the propensity to betrayal. The Valentine’s Day party dedicated to lovers is perhaps one of the most romantic days for new couples, but for long-standing couples in which they get by tiredly and without great enthusiasm, it is instead the time for uncomfortable questions: why love doesn’t last? Why does one no longer experience sexual pleasure? We turned these questions to Barry R.