by Paolo Becchi e Nicola Trevisan
In this article, we report a study of 06 August 2021, with the aim of soliciting the reader to consider the benefit-risk of vaccinating populations under the age of 20 years, a target much desired and longed for by our CTS, the Ministry of Health and super-star virologists.
The study analyzed 3,998 individuals for whom adverse events (within 30 minutes of inoculation of the first dose of Moderna) occurred on 20 individuals equal to 0.05%; including 1 severe anaphylaxis in a woman.
The survey questionnaire issued for the collection of observations was completed by 1,993 subjects (49.8% of the total); 1,887 of these agreed to participate in the study. With a distribution of 66% women and 34% men; 24% were under the age of 20.
Table 3 summarizes the ade detected: general and systematic adverse events were generally “mild”; 82% experienced local pain; 71% pain at the injection site, while the ade systemic occurred in 48%. L’ade most common was myalgia 34% and fatigue 31%.
However, almost all of them symptoms improved without any treatment. The percentage of participants with local itching and redness after day 7 were 27% and 19%, respectively. The onset of myalgia occurred on the same day and the day after the injection (98%) and symptoms persisted for 2-3 days, somewhat longer than other systemic adverse reactions (73%). Of those who developed symptoms, 75% did not undergo any treatment and 17% were given paracetamol. General fatigue often occurred on the day of injection (94%) and continued for the next 2-3 days (66%).
An important evaluation of the study was directed to the female population, dividing it by those who presented a history of allergic events (AE), with those who have never experienced such problems (NO-AE). Table 4 summarizes the analyzed sample: it is noted that there is a greater historical AE for local adverse events compared to NO-AE; while for systemic adverse events, the situation was almost similar.
The results of the multivariate analysis of the AE and No-AE groups are shown in Table 5. We leave it to the reader to analyze the details on pages 10-11 of the pdf file that can be downloaded free of charge. link.