Ange Postecoglou has received a lot of praise for the work he has done since being appointed Tottenham manager.
Tottenham, who topped the table in October, are currently in fourth place and Ferguson feels they will never win the title.
The last time Tottenham won the league was in the 1960-61 campaign, when Bill Nicholson was in charge.
Ferguson won the league 13 times as United manager before retiring in 2013.
Asked by Sky Sports Racing’s Matt Chapman if Tottenham will ever win the Premier League, Ferguson responded by saying: “No” before laughing.
Ferguson continued: “1961 was the last time they won it. That’s a long time. “Today’s proposal with Liverpool and Man City is so powerful in the Premier League.”
The 82-year-old was interviewed at Newbury Racecourse, where his horse Protektorat came third in the Betfair Denman Chase.
When Chapman suggested Tottenham were more likely to win the league than United, Ferguson said: “No chance.”
Ferguson once said: “Lads, it’s Tottenham,” as his team spoke when they faced the north London club at home.
Tottenham beat Brighton 2-1 at home on Saturday, with Brennan Johnson scoring the late equaliser.
Tottenham beat Brighton 2-1 but Ferguson feels they will never win the title again