Cellular “crosstalk” that triggers pancreatic cancer cachexia discovered.
Posted by giorgiobertin on April 13, 2024
A new research ofUniversity of Oklahoma reveals a previously unknown chain of events that triggers the development of cancer cachexia, a debilitating condition of muscle wasting that almost always occurs in people diagnosed with pancreatic cancer.
The researchers found that communication between pancreatic cancer cells and macrophages leads to the onset of cachexia. Macrophages, usually responsible for defense against infections, are recruited by tumor cells to cause damage. This interaction leads to increased secretion of a protein called TWEAKwhich is involved in the development of cachexia by binding to muscle cells and causing inflammation.
Lo studio demonstrated that communication between tumor cells and macrophages underlies cachexia, offering a therapeutic window to intervene and potentially halt or reduce cachexia. This could improve the prognosis for patients with pancreatic cancer, which currently has a low five-year survival rate.
Read the full text of the article:
The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia
Mingyang Liu,…. et al.
Cancer Cell Available online 11 April 2024
Source: University of Oklahoma
This entry was posted on aprile 13, 2024 a 6:11 am and is filed under News-research. Tagged: biology, Gastroenterology, oncology. You can follow any responses to this entry through the RSS 2.0 feed.
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