He has been vaccinated 217 times against Covid, and without any side effects. The man is a 62-year-old from Madeburg (Germany), whose story, which became a case, was told by the scientific magazine The Lancet. It must be said that the protagonist of this story said he was well aware of having been vaccinated many more times than recommended by the scientific community. And his decision, explain the researchers of Friedrich Alexander University and of Erlangen-Nurembergit is due to “personal reasons”.
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Over 7 vaccinations per month for 29 months
The over 200 vaccine administrations to which the man underwent were carried out over 29 months, in practice more than 7 per month, and at least 130 of these were confirmed by an investigation by the Magdeburg prosecutor’s office, which investigated the case, but without formally charging the 62-year-old.
Scientists became aware of the case through newspaper reports. And until now it was unclear what effects a hypervaccination like this had on the immune system. In particular, some experts believed that the immune cells of the over-vaccinated person would become less efficient after becoming accustomed to the antigens, which however did not happen.
“I got vaccinated for private reasons”
More than 60 million people in Germany have been vaccinated against SARS-Coronavirus 2, most of them multiple times. But the 62-year-old from Magdeburg beat everyone. The man, who was analyzed by researchers, claims to have received 217 vaccinations “for private reasons”. And for 134 of these vaccinations there is official confirmation. “We learned about his case through newspaper articles,” he explained Kilian Schober, of the Universitatsklinikum Erlangen -. So we contacted him and invited him to undergo various tests in Erlangen. She was very interested in doing it.”
As a rule, vaccinations contain parts of the pathogen or some type of building block that the cells of the vaccinated person can use to produce these pathogen components themselves. Thanks to these antigens, the immune system learns to recognize the real pathogen in the event of a subsequent infection.
“If the body’s immune system is exposed extremely frequently to a specific antigen, it may be the case of a chronic infection, such as HIV or hepatitis B, which presents regular flare-ups – underlined Schober -. It has been demonstrated that certain types of immune cells, known as T cells, become fatigued and release fewer pro-inflammatory messenger substances. This and other effects triggered by the cells becoming accustomed to antigens can weaken the immune system, making it unable to fight the pathogen in effective way. The current study, which also involved researchers from Munich and Vienna, does not, however, provide any indication in this sense.”
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Blood tests
Schober continued: “The man, who has undergone several blood tests in recent years, allowed us to carry out evaluations on the results of these tests. In some cases, the samples had been frozen and we were able to analyze them ourselves Furthermore, we were able to take blood samples when the man received an additional vaccination during the study, at his own insistence.” The expert clarifies: “We used these samples to determine exactly how the immune system reacts to vaccination.”
The results showed that the 62-year-old has a large number of effector T cells against SARS-CoV-2. These act as the body’s soldiers fighting against the virus. And he even had more than the control group of people who had received three vaccinations. The researchers did not perceive any fatigue in these effector cells, which were as effective as those in the control group that had received the expected number of vaccinations.
Explore memory T cells
The researchers then explored memory T cells, which are in a preliminary stage, before effector cells. Similar to stem cells, these can replenish the number of adequate effector cells. “The number of memory cells was equally high in both the humans and the control group,” he explained Katharina Kocher, among the main authors of the study -. Overall, we found no indication of a weaker immune response, quite the opposite. Furthermore, the 217th vaccination received by the man during the study also had an effect: the number of antibodies against SARS-CoV-2 increased significantly.”
Further testing indicated that the immune system’s effectiveness against other pathogens was not changed. It therefore appears that hypervaccination did not damage the immune system as such.
Eight different vaccines administered
“The man was immunized with a total of eight different vaccines, including some available mRNA vaccines – highlighted Schober -. The fact that no noteworthy side effects occurred, despite this extraordinary hypervaccination, indicates that the drugs have a good degree of tolerability. However, this is a single case. And the results are not sufficient to draw far-reaching conclusions, much less to make recommendations for the general public.” He concluded: “Current research indicates that a three-dose vaccination, combined with regular supplementary vaccines for vulnerable groups, remains the preferred approach; there is, therefore, no indication that additional vaccines are necessary.”
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“The immune system is not tired”
The surprising fact of an immune system which, despite being stimulated by 217 vaccinations has not, so to speak, tired, also underlines it Mario Picozza researcher at the S.Lucia institute in Rome. Which underlines: “A few years ago, when booster doses of the vaccine began to be administered, there was concern, even on the part of some studies, that after repeated solicitations of the cells of the immune system responsible for recognizing the virus, these would encounter to a phenomenon of exhaustion, tiredness due precisely to repeated stress. The case of the multiple-vaccinated man demonstrates that this does not happen”. “On the other hand, it is also true that in this case the increase in immunity against the virus does not seem to be so marked compared to those who have undergone normal vaccination cycles, therefore the advantages are very few and this practice is not recommended – he concludes Ax immune system does not become less reactive and effective against the SARS-CoV-2 virus.”