A new, important piece of knowledge on the risks of occurrence of is added myocarditis and pericarditis in people who have been vaccinated for Sars-CoV-2. And it is a confirmation of the benefit of the Rna-messenger vaccine (in about 3% of cases the path after vaccination with the Johnson & Johnson vaccine was also followed), also in this respect, compared to the risk of natural infection.
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The analysis, which appeared on Jama and coordinated by George A. Diaz, of Everett’s Providence Regional Medical Center looks at more than two million people in forty hospitals in Washington, Oregon, Montana and Los Angeles County, California who have had at least one vaccination for Covid-19.
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Thanks to the data collection, the population (average age 57 years in almost six out of ten female cases) correlated the monthly rates of hospital diagnosis of myocarditis and pericarditis before the vaccine and after its availability. Vaccination-related myocarditis was observed in 20 people, occurring on average 3-4 days after inoculation, and pericarditis in 37 cases.
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As for myocardial inflammation, the average age was 36 years, four people developed symptoms after the first vaccination and sixteen after the second. Only one patient observed did not need hospitalization, which lasted on average only two days, it must also be said that among these patients there were no deaths or new hospitalizations and that the trend in remote controls was globally positive.
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Chapter pericarditis, or inflammation of the membrane that covers the heart. In 15 patients the event (more advanced average age, around 60 years) occurred after the first vaccination, and in 22 after the booster. Generally, the picture occurred later than myocarditis, on average twenty days after the last vaccination dose was administered. There was no need for any ICU admission and no patient died. An improvement was noted in the follow-up patients (on average about a month) in the follow-up patients. It must be said that in the pre-vaccination period the average number of cases of myocarditis and pericarditis was lower than that observed in the vaccination period.
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“The study provides important information on the occurrence of myocarditis and pericarditis (inflammation of the wall of the heart or of the membrane that covers it, respectively) that occurred in over 2 million individuals vaccinated in the US in a little over a year – he comments Pasquale Perrone Filardi, Professor of Cardiology at the Federico II University of Naples and elected president of the Italian Society of Cardiology (Sic). The observed incidence of myocarditis was one case per 100,000 vaccinated subjects, and mainly concerned the younger groups (mean age 36 years). This is a much lower incidence than the “natural” one, ie that of unvaccinated subjects, equal to 22 cases per 100,000 subjects. The same goes for pericarditis, which concerns older subjects, with an incidence of 1.8 cases per 100,000 vaccinated ”.
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How to explain these figures after administration of mRNA vaccines? “An inflammatory reaction, induced by the immune response to the administration of the vaccine, is probably the cause of these side effects, the benign nature of which, also emerged from this observation, makes the benefit-risk profile absolutely favorable to the vaccine – says the expert. In fact, it should be remembered that the European CDC data updated to August 2021 tell us that the lethality of the virus in Italy (i.e. the number of deaths for individuals affected by the infection) stands at 2.9%. For this reason we now have another important population study that adds important evidence to the favorable risk / benefit profile of mRNA vaccines. ”
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