And drug approved for the treatment of diabetes type 2 is extremely effective in reducing theobesity. According to the results of the study, published in The New England Journal of Medicine, everyone who took it lost up to 21% of their body weight – about 24 kg in some cases. The preparation, called tirzepatide, acts on two natural hormones that help control blood sugar and are involved in sending fullness signals from the gut to the brain.
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“Nothing has provided that kind of weight loss except surgery,” said Dr. Robert Gabbay, scientific and medical director of the American Diabetes Association. About 15% of participants who received the active drug dropped out of the 72-week study, about one-third due to gastrointestinal side effects. 26% of the study volunteers who received a placebo dropped out. Emmick said he thinks they may have been frustrated by their lack of weight loss.
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The tirzepatide study, called SURMOUNT-1, included more than 2,500 volunteers meeting the medical definition of obesity, with a body mass index of 30 or higher, or with at least one weight-related health problem. For most of the participants, the drug’s side effects were not serious, with only 15% of them dropping out of the 72-week study experiencing gastrointestinal tract-related problems.