Venue: Twickenham, London Date: Saturday, 10 February Kick-off: 16:45 GMTCoverage: Watch live on S4C; listen on BBC Radio 5 Sports Extra, BBC Radio Wales & Radio Cymru; text commentary on BBC Sport website and app.
Wales flanker James Botham has been released from the Six Nations squad because of a knee injury with prop Dillon Lewis and lock Seb Davies called up.
Botham started and scored a try in the 27-26 defeat to Scotland but has been sent back to his club Cardiff for rehabilitation.
Lewis becomes the fourth Wales tight-head option in the squad.
Wales travel to face England on Saturday at Twickenham.
Davies can play lock or in the back row while Cardiff flanker Alex Mann replaced Botham against Scotland and scored a try on his international debut.
Mackenzie Martin and Taine Basham are the other back-row options with Taulupe Faletau and Jac Morgan missing through long-term injuries.
Prop Brown started the game against Scotland but was forced off at half-time through injury and replaced by Keiron Assiratti. Bath uncapped prop Archie Griffin is the other option in the squad.
Lewis, 28, has played 54 internationals for Wales. The former Cardiff man was one of three tight-head props selected for the 2023 World Cup, alongside France-based Henry Thomas and Tomas Francis, who were not included in the original Six Nations squad.
Fly-half Sam Costelow is a doubt to face England having being forced off the field in the first half with a head injury after being cleared out of a ruck.
He was replaced by Ioan Lloyd who is in line for a first Wales fly-half start at Twickenham.