How chromosomal imbalances can drive cancer.
Posted by giorgiobertin on July 1, 2023
The vast majority of cancer cells have too few or too many copies of some chromosomes, a state known as aneuploidy. But for decades, researchers have debated whether aneuploidy promotes the growth of tumors or is simply a side effect of the rapid growth of cancer cells. Such large-scale changes in DNA have been difficult to study.
Credito: Ricardo Job-Reese, Broad Communications
Now, the researchers of the Broad Institute from MIT and Harvard and the Dana-Farber Cancer Institute discovered, thanks to a computational tool they developed, that aneuploidy drives cancer progression.
The research will point to new drug targets or ways to screen cancer patients for the most effective treatment.
Read abstract of the article:
Cancer aneuploidies are shaped primarily by effects on tumour fitness.
Shih, J., Sarmashghi, S., Zhakula-Kostadinova, N. et al.
Nature (2023).
Source: Broad Institute
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This entry was posted on luglio 1, 2023 a 7:23 am and is filed under News-search. Marked by tags: biochemistry, biology, genetics, oncology. You can follow any responses to this entry through the RSS 2.0 feed.
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