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When you swallow a lozenge or have an injection or other treatment that affects your health, if you believe it works better. The meaning of the American study, published in Jama Surgery, based on the historical comparison of the results of antibiotic drugs and appendectomy (CODA). Carried out between May 2016 and February 2020, the study led to the acceptance of antibiotics as a first-line treatment for appendicitis.