He runs all night, works hard to keep fit, spends a lot of energy. Is the result? A psycho-physical well-being that is also transferable to those who do not care about physical activity. How transferable? Yes, word of a mouse, for now at least. A study on Nature describing how the brain benefits of marathon mice benefit their peers, the so-called “couch potatoes”. On the other hand, it is known that muridae love to run and juggle as acrobats on the wheel that turns endlessly. And if someone blocks it and the game stops, goodbye to planned well-being.
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Researchers at the Stanford School of Medicine have discovered that at the base of the benefit, “acquired” and usable by sedentary patients, there is a protein, clusterin, present in the blood of marathon mice. It means that if a similar result were demonstrated in humans, which is obviously far from obvious and in any case not around the corner, a door could open to targeted treatments to limit the onset or progression of degenerative diseases in patients at risk and not inclined to sporting activity. Which, however, remains an important source of well-being, a priori.
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In detail, the study (lead author, Zurine De Miguel, former professor of psychology at California State University, Monterey Bay) enrolled two groups of mice of the same age, trained and sedentary (forced into enforced laziness), comparing their respective blood samples. Well, blood transfusion from running mice into their lazy counterparts has shown in the latter not only a reduction in neuroinflammation, but also an improvement in cognitive performance.
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In fact, clusterin transmitted by the blood has a significant anti-neuroinflammatory role which would then have a positive effect on cognitive health as well. Further experiments showed that clusterin binds to receptors that abound on brain endothelial cells, the inflamed cells in most Alzheimer’s patients.
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“Neuroinflammation in men – explains, in fact, Tony Wyss-Coray, a neuroimmunologist at Stanford University – is strongly related to neurodegenerative diseases. Animal studies reveal that a reduction in neuroinflammation would correspond to a prolongation of cognitive function. That is, attention, memory, perception and reasoning “.
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The scientist points out that even those affected by the flu can experience a loss, a consequence of the viral infection that induces the fever: “You become drowsy and you feel disconnected, with the brain that seems to go narrow gauge. On the other hand, it is. it is now certain – he adds – that neuroinflammation also favors the progression of Alzheimer’s and other neurodegenerative diseases “.
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Finally, to confirm the elevated levels of clusterin only in trained subjects is also an experiment carried out on patients with cognitive impairment: monitored for six months and subjected to physical exercise, they recorded a significant increase in plasma protein.
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