Lianhua Qingwen Capsules(grain)Since its listing, according to the statistics of its manufacturer, Yiling Pharmaceutical, it has been recommended 27 times by the guidelines for the treatment of colds, anti-influenza, and prevention and treatment of new crowns. However, disputes and doubts surrounding its effectiveness have never ceased.On April 17, the WeChat public account “Rao Yixue” issued an article “During the Epidemic: Fake medicines are not allowed to take advantage of the fire, and unproven traditional Chinese medicines should not be forcibly delivered”, pointing the finger at Lianhua Qingwen Capsules (granules). The official WeChat account belongs to Professor Rao Yi, President of Capital Medical University. The text reads:
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Today, in areas ravaged by the new crown, the allocation of materials is tense.Sometimes, in some areas, it is difficult to guarantee that the food and medicines the people need will reach the masses on time.In this situation,If drugs for the prevention or treatment of the new crown are forced to be distributed, they must be strictly inspected, and fake and inferior products must not be allowed to wear any hats.——Hats including “Chinese medicine”——forcibly distributed to the masses.
Because if it is a fake drug, it is not only useless, but also affects the distribution of important materials.
If it is a fake medicine, wearing the hat of “traditional Chinese medicine” will damage the reputation of real and effective traditional Chinese medicine and affect the credibility of real and effective traditional Chinese medicine.
In Shanghai, where the new crown epidemic is raging, many families are worried about food, and there may be a lack of emergency medicines at home, but there must be no shortage of Lianhua Qingwen.Under the situation that the food purchased online is difficult to deliver, Mr. Tian, who lives in a closed community in Hongkou District, has received four boxes of Lianhua Qingwen Capsules twice.(grain)Now, the vegetables sent by the community are only received once.
A piece of information on the homepage of Yiling Pharmaceutical’s official website stated that following the donation of 10 million yuan worth of Lianhua Qingwen to Shanghai on March 28, Yiling Pharmaceutical again urgently donated 50 million yuan to Lianhua Qingwen on April 3. Help Shanghai epidemic prevention and control.
Lianhua Qingwen Capsules(grain)It should be the only medicine distributed to prevent or treat the new crown during the Shanghai epidemic. In this regard, Professor Rao Yi pointed out sharply in the article:
It needs to be very clear whether “Lianhua Qingwen” has indeed been proven to be effective in preventing or treating the new crown.
If “Lianhua Qingwen” has never been strictly proven to be effective, then the forced delivery of “Lianhua Qingwen” will harm the masses waiting for necessary supplies and medicines.
Representative figures such as Wu Yiling, his companies, and their products have faced huge disputes over the years between genuine and counterfeit medicines, and should be strictly reviewed. If it is real medicine, it should be clear. If it is a counterfeit medicine, it should be severely punished, and the punishment should be a warning to a hundred people, and we should eradicate the liars, their companies, and their products who dare to take advantage of the epidemic during the epidemic.
Before Professor Rao Yi published the article, the “Bedtime News Editorial Department” pushed a “Bedtime News 417: WHO “recommended” Lianhua Qingwen, who told you? ” video, which verified the news that the World Health Organization recommended Lianhua Qingwen previously circulated on the Internet, and the news caused Yiling Pharmaceutical’s stock price to rise by the limit twice.
The “bedtime news editorial department” came to the conclusion after verification that: the mainstream media in China just linked the Chinese people to the World Health Organization meeting with Lianhua Qingwen Capsules, creating a wrong understanding of the masses, not only forcibly establishing contact, It can even be said that it is a medal for scandal.
In the video, the “send medal for scandal” refers to the fact that Jia Zhenhua, the son-in-law of Yiling Pharmaceutical’s founder Wu Yiling, concealed his relationship with Yiling Pharmaceutical in his signed paper on the effectiveness and safety of Lianhua Qingwen. matter of interest. The paper, titled “Efficacy and Safety of Traditional Chinese Medicine Lianhua Qingwen Capsules in COVID-19 Patients: A Multicenter, Prospective Randomized Controlled Trial”, was published in Phytomedicine in May 2020.
One year after the paper was published, Retraction Watch, a well-known scientific research anti-counterfeiting website, pointed out that Jia Zhenhua, one of the signed authors of the paper, failed to disclose his personal interests with the pharmaceutical company in the paper. Jia Zhenhua is the son-in-law of Wu Yiling, the founder of Ling Pharmaceutical, and he His wife is a member of the board of directors of Yiling Pharmaceutical. The husband and wife also jointly operate a subsidiary of Yiling Pharmaceutical, which is a subsidiary of Lianhua Qingwen Capsules.(grain)the only production company.
Jia Zhenhua admitted his interest connection with Yiling Pharmaceutical in the errata document later submitted to “Botanical Medicine”, but denied that his company had participated in clinical trials. Although he was the corresponding author, he did not participate in the actual work of the paper. Research or statistical analysis, his participation will not reduce the objectivity of the paper’s conclusions, Yiling Pharmaceutical also provided some funds and required drugs for the research, but did not exert influence on the paper.
The video of the “Bedtime News Editorial Department” stated that the original paper clearly stated that the study did not carry out a double-blind trial, neither concealed drugs from patients, nor designed a placebo control. Even if Jia Zhenhua’s interests were ignored, this paper Nor does it offer many credible conclusions.
On April 14, this video of the “Bedtime News Editorial Department” was forwarded by Wang Sicong, who wrote in the forwarding comment: The China Securities Regulatory Commission should strictly investigate Yiling Pharmaceutical. Wang Sicong’s repost attracted huge attention. On April 15, Yiling Pharmaceutical’s stock price fell by the limit. After that, Wang Sicong edited the Weibo, deleted the comments, and only kept the forwarded video.
Lianhua Qingwen Capsules(grain)How effective is it?In the instructions of Lianhua Qingwen Granules, there is a paragraph about “pharmacology and toxicology”: in vitro experiments show that this product is effective against influenza virus and parainfluenza virus type I.（HVJ-1）respiratory syncytial virus（RSV）adenovirus types 3 and 7(ADV3 and ADV7)herpes simplex virus type I（HSV-1）And type 2, SARS virus, Staphylococcus aureus, A, B hemolytic streptococcus, pneumococcus, influenza bacillus have certain inhibitory effect.
Regarding the above description, the famous doctor V “Chengdu Sewer” commented: There are too many things that have an inhibitory effect on the virus in vitro, including alcohol, iodophor, disinfectant and even boiled water. Since the end of 2019, in the global anti-epidemic that has continued to this day, arbidol, darunavir, chloroquine phosphate, and remdesivir, which had high hopes, have a strong inhibitory effect on the new coronavirus in vitro, but are really used for Human trials have all failed in the battle against the new coronavirus.
“Effective in vitro is the result of in vitro cells in the laboratory. It is still far from the earth to Mars. Now that there are enough patients, Lianhua Qingwen should be patient and complete rigorous medical tests step by step. “Chengdu Sewers” wrote.
Despite facing huge controversy over the years, Lianhua Qingwen Capsule has not been hindered(grain)It has been recommended for 27 times in the guidelines for treating colds, anti-influenza, and preventing and treating new crowns.
Regarding the new coronary pneumonia, although the “function and indications” of Lianhua Qingwen Granules clearly states: in the conventional treatment of new coronavirus pneumonia, it can be used for fever, cough, and fatigue caused by mild and common types.However, on March 24, the Hebei Provincial Administration of Traditional Chinese Medicine issued the “Hebei Province New Coronary Virus Pneumonia Traditional Chinese Medicine Prevention and Control Plan”.(Trial version 6)“, Lianhua Qingwen Capsule(grain)It is not only recommended for medical observation period, asymptomatic infection, mild, common and severe new crown patients, but also recommended as preventive medicine for adults and children.
In the “Ten Questions about the Prevention of New Coronary Pneumonia with Traditional Chinese Medicine” published on the official website of the Shanghai Municipal Health Commission and the Shanghai Administration of Traditional Chinese Medicine, Lianhua Qingwen Capsules(grain)It is also recommended as a Chinese patent medicine for prophylaxis.
However, according to the “Shangguan News” report, Dr. Fang Hong, director of the Department of Preventive Health Care of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, reminded that Lianhua Qingwen is a therapeutic drug, not a preventive drug. No fever, sore throat, cough and other symptoms, it is not recommended to take.
Professor Fang Bangjiang, director of the emergency medicine department of Longhua Hospital, also said that Lianhua Qingwen is not suitable for preventive medicine. Chinese herbal medicine contains a lot of electrolytes. People with poor spleen and stomach functions, gastric ulcers, and poor liver and kidney functions are not suitable for taking this medicine. .Attention needs to be paid to inappropriate preventive measures.
Written by | Tian Dongliang
Source | “Medical Community” public account